.. blogpost:: :title: pythonnet for Python 3.5 :keywords: pythonnet, .net, C#, python, issue :date: 2016-01-03 :categories: install, module, pythonnet People usually install modules from `Unofficial Windows Binaries for Python Extension Packages `_ on Windows. This also goes for `pythonnet `_ which was compiled this github repository. This release works somehow for Python 3.5 but fails if some functionalities are required. You can try:: import clr clr.__dict__ The module does not seem to be maintained an a regular basis. So I tried to make some changes to make it work for Python 3.5: `pythonnet-2.1.1-cp35-none-win_amd64.whl `_. The source are available at: `sdpython/pythonnet3 `_. Some changes were needed to replicate the changes in Python API introduced by Python 3.5. The Python API and its duplication in C# on Pythonnet side must match otherwise some unexpected error will happen. A classical C++ error as Python or Pythonnet is going to overwrite some memory it should not access. Debugging is still uneasy. Maybe I missed something. I downloaded the source from `Python website `_ and I inserted many prints to understand where the module was stuck:: cd C:\github\pythonnet\pybin\x64\Release35 D:\python_source\Python-3.5.1\PCbuild\amd64\python -c "import clr;print(clr.__dict__);print(type(clr))" However, with this new version, the following instruction fails:: array = numpy.ones((2,2)) File "test_pythonnet.py", line 97, in test_pythonnet_array ar = IntPtr.__overloads__[int](array.__array_interface__['data'][0]) TypeError: no constructor matches given arguments It is now replaced by:: array = numpy.ones((2,2)) from clr import IntPtr_long ar = IntPtr_long(array.__array_interface__['data'][0]) Pythonnet was compiled with for Python 3.5 with Visual Studio 2015 (Free Community Edition). However you might face the following error:: Unhandled Exception: System.IO.FileLoadException: Could not load file or assembly 'file:///\Python.Runtime.dll' or one of its dependencies. Operation is not supported. (Exception from HRESULT: 0x80131515) ---> System.NotSupportedException: An attempt was made to load an assembly from a network location which would have caused the assembly to be sandboxed in previous versions of the .NET Framework. This release of the .NET Framework does not enable CAS policy by default, so this load may be dangerous. If this load is not intended to sandbox the assembly, please enable the loadFromRemoteSources switch. See http://go.microsoft.com/fwlink/?LinkId=155569 for more information. --- End of inner exception stack trace --- at System.Reflection.RuntimeAssembly._nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks) at System.Reflection.RuntimeAssembly.InternalLoadAssemblyName(AssemblyName assemblyRef, Evidence assemblySecurity, RuntimeAssembly reqAssembly, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks) at System.Reflection.RuntimeAssembly.InternalLoadFrom(String assemblyFile, Evidence securityEvidence, Byte[] hashValue, AssemblyHashAlgorithm hashAlgorithm, Boolean forIntrospection, Boolean suppressSecurityChecks, StackCrawlMark& stackMark) at System.Reflection.Assembly.LoadFrom(String assemblyFile) at clrModule.PyInit_clr() In that case, I suggest to get the source and to compile them with Visual Studio 2015 on your machine, it should import the missing DLL which I'm still trying to find out. The DLL was compiled on an Azure Virtual Machine. You might have to recompile it on your own machine. The changes needed for Python 3.5 / 3.4 are highlighted in the following commit `update source code for Python 3.5, from fkarb/pythonnet + sdpython/py… `_ and `update project `_.