.. blogpost:: :title: Install pythonnet on debian is difficult :keywords: python, debian, pythonnet :date: 2021-01-15 :categories: installation From `Install the .NET SDK or the .NET Runtime on Debian `_. :: wget https://packages.microsoft.com/config/debian/10/packages-microsoft-prod.deb -O packages-microsoft-prod.deb sudo dpkg -i packages-microsoft-prod.deb sudo apt-get update sudo apt-get install -y apt-transport-https sudo apt-get install -y dotnet-sdk-5.0 sudo apt-get install -y aspnetcore-runtime-5.0 sudo apt-get install -y dotnet-runtime-5.0 Then build `pythonnet `_: :: git clone https://github.com/pythonnet/pythonnet cd pythonnet python3.9 setup.py build_dotnet python3.9 setup.py bdist_wheel Unfortunately, *pythonnet* does not work with *dotnet* yet on linux. *mono* is still needed (see `Add the Mono repository to your system `_). :: sudo apt install apt-transport-https dirmngr gnupg ca-certificates sudo apt-key adv --keyserver hkp://keyserver.ubuntu.com:80 --recv-keys 3FA7E0328081BFF6A14DA29AA6A19B38D3D831EF echo "deb https://download.mono-project.com/repo/debian stable-stretch main" | sudo tee /etc/apt/sources.list.d/mono-official-stable.list sudo apt update sudo apt install mono-devel nuget mono --version The package `dotnetcore2 `_ might be needed. This is a work in progress.